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ea0029p789 | Endocrine tumours and neoplasia | ICEECE2012

The pathogenesis of non functioning pituitary adenoma with positive staining for glycoproteins is associated with MEG3/DLK1 underexpression/GSTP1 overexpression and modulated by microRNAs (miRNAs)

Paixao B. , Lima D. , Peitl P. , Dinarte A. , Saggioro F. , Moreira A. , Silva W. , Machado H. , Castro M.

Context: Pathogenesis underlying non functioning pituitary adenoma (NFPA) formation and progression has not been well established. MEG3 is strongly expressed in the normal pituitary (NP) but not in NFPA derived from gonadotroph cells. High GSTP1 gene expression also seems to contribute to gonadotroph adenoma development. Recent reports indicate a role of miRNAs in the pituitary adenoma pathogenesis.Objective: To evaluate the expression of MEG3, DLK1, GST...

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ea0029p834 | Endocrine tumours and neoplasia | ICEECE2012

Expression of MAPK7 and CCNL1 in corticotrophinomas and functional analysis of miR-143 and miR-145 in corticotrophic tumoral lineage AtT20

Camargo R. , Paixao B. , Colli L. , Varanda W. , Rodrigues J. , Elias L. , Castro M.

Introduction: miR143 and 145 seem to be involved in the pathogenesis of cortitotrophinomas by modulating the expression of MAPK7 and CCNL1 genes, which protein products are involved in cell proliferation, differentiation, and cell cycle progression. Objective: To analyze the modulation of miR-143 and -145 in the expression of MAPK7 and CCNL1 genes in corticotrophinomas and corticotrophic tumoral lineage (AtT20).Material and Methods: The expression of MAP...

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Endocrine Abstracts

The pathogenesis of non functioning pituitary adenoma with positive staining for glycoproteins is associated with MEG3/DLK1 underexpression/GSTP1 overexpression and modulated by microRNAs (miRNAs)

Expression of MAPK7 and CCNL1 in corticotrophinomas and functional analysis of miR-143 and miR-145 in corticotrophic tumoral lineage AtT20

BiosciAbstracts